The PGU-14/B is the most frequently fired uranium munition. It was developed with the intention of being able to penetrate tanks, with development completing in the mid 1970s, and deployment to NATO forces in europe in 1978. It is known to have been fired in Iraq, Bosnia, Serbia and Kosovo.

Although it was developed for the A-10 Thunderbolt aircraft (colloquially known as the 'Warthog'), it is part of a family of 30 x 173 mm ammunition. Guns which shoot rounds of this type include:

• GAU-8/A, found in the A-10 and used in the Goalkeeper Close In Weapons System on numerous ships
  
• MK 44 Bushmaster II, found in the Bionix II Armoured Fighting Vehicle (AFV), and planned for the US Marines Expeditionary Fighting Vehicle (EFV)
• Mauser MK 30, found on German and Itallian Ships

However, the PGU-14/B is only thought to have been used with the A-10. The round is manufactured by both General Dynamics-Ordnance Tactical Systems in Marion, Illinois,  and Alliant Techsystems in New Brighton, Minnesota. The round contains a penetrator made with uranium alloyed to another metal.

In the A-10, the PGU-14/B is used alongside the PGU-13 High Explosive round. The usual ratio is 5 PGU-14 for every PGU-13. A third round, the PGU-15/B Target Practice round, is ballistically matched to the other two rounds, in order to allow trainees to practice with a low cost alternative. General Dynamics state that, taking these three types together, they have produced more than one hundred million rounds. Figures for the number produced by Alliant Techsystems are not known

In early 2010, ICBUW broke the story that the United States was moving away from using uranium in medium calibre rounds. The Joint Strike Fighter, planned to replace the A-10, is being tested with the Rheinmetal all purpose Frangible Armour Piercing round containing tungsten.