Conclusions from in Vitro studies:

1. DU induces neoplastic transformation, mutagenicity, and genotoxicity in vitro.
2. DU is involved in uranium-induced genomic instability.
3. Alpha particles similar in energy and distribution to those resulting from cellular uranium exposure to DU are sufficient to transform cells.
4. Radiation bystander effects are involved in uranium-induced neoplastic transformation and genomic instability.

Attachments

• A Review of Depleted Uranium Biological Effects: In Vitro Studies

  4875 Kb - Format pdf
  Dr Alexandra Miller - Source: http://dodreports.com/pdf/ada539809.pdf
  Presentation by Dr Alexandra Miller of the US Armed Forces Radiobiology Research Institute (AFRRI) compiling the in vitro research by AFRRI and others into the biological effects of depleted uranium exposure. Conclusions from in Vitro studies: 1. DU induces neoplastic transformation, mutagenicity, and genotoxicity in vitro. 2. DU is involved in uranium-induced genomic instability. 3. Alpha particles similar in energy and distribution to those resulting from cellular uranium exposure to DU are sufficient to transform cells. 4. Radiation bystander effects are involved in uranium-induced neoplastic transformation and genomic instability.